Revolutionizing Cannabinoid Stability

We are excited to share the recent results from our cannabinoid formulation development program. 

Enhanced Bioavailability and Potency

Cannabidiolic acid (CBDA), the prominent cannabinoid in hemp, is known to have a bioavailability much greater than that of the neutral form of CBD. Similarly, the AUC after oral administration of oil containing THCA was shown to be 25 times greater than with THC (Pellesi 2018). It is widely known that acidic cannabinoids like CBDA, CBGA, THCA, and THCVA exhibit much more potent biological activity than their neutral counterparts in many medical indications, and these high potencies do not require decarboxylation. 

Stability Challenges

Although acidic cannabinoids have shown promising clinical benefits in a wide range of indications from acute pain to seizure control, their practical use is blocked by rapid degradation during manufacturing and storage. In prior formulations, these purified acidic forms often convert into lower-potency forms from decarboxylation and oxidation processes. These transformations are self-catalytic, occurring at room temperature and even under refrigeration. Achieving cannabinoid formulations that will repeatedly, reliably, and cost-effectively meet the rigid requirements for stable commercial products is an absolute necessity for unlocking the clinical promise and commercial value of acidic cannabinoids.

Innovative Technology

We take immense pride in introducing our patent-pending intercalation technology, which provides long-term protection for acidic cannabinoids from decarboxylation, oxidation, exposure to UV light, and elevated temperatures over extended periods. 

Proven Stability

The graph below illustrates the stability of Mingowood’s CBDA formulation, displaying ATR FTIR data collected before and after subjecting the formulation to 25 days at 50°C. The characteristic peak positions of CBDA remain intact throughout the heat stress period with no signs of degradation. 

The stability of Mingowood's CBDA formulation is illustrated in this graph of ATR-FTIR data taken before and after stressing for 3.5 weeks at 50°C: